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Improved health-related quality of life in patients treated with topical sirolimus for facial angiofibroma associated with tuberous sclerosis complex
Takashi Hatano, et al. Orphanet J Rare Dis. 2020 Jun 1;15(1):133.
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Safety and Efficacy of the Sirolimus Gel for TSC Patients With Facial Skin Lesions in a Long-Term, Open-Label, Extension, Uncontrolled Clinical Trial.
Wataya-Kaneda M, et al. Dermatol Ther (Heidelb). 2020 May 8.
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Early Sirolimus Gel Treatment May Diminish Angiofibromas and Prevent Angiofibroma Recurrence in Children With Tuberous Sclerosis Complex.
Okanishi T, et al. Front Med (Lausanne). 2020 Jan 22;7:1.
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Sirolimus Gel Treatment vs Placebo for Facial Angiofibromas in Patients With Tuberous Sclerosis Complex: A Randomized Clinical Trial.
Wataya-Kaneda M, et al. JAMA Dermatol. 2018; 154(7): 781-788
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Efficacy and Safety of Topical Sirolimus Therapy for Facial Angiofibromas in the Tuberous Sclerosis Complex : A Randomized Clinical Trial.
Wataya-Kaneda M, et al. JAMA Dermatol. 2017; 153(1): 39-48
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Clinical and Histologic Analysis of the Efficacy of Topical Rapamycin Therapy Against Hypomelanotic Macules in Tuberous Sclerosis Complex.
Wataya-Kaneda M, et al. JAMA Dermatol. 2015; 151(7): 722-730
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Improvement of tuberous sclerosis complex (TSC) skin tumors during long-term treatment with oral sirolimus.
Nathan N, et al. J Am Acad Dermatol. 2015; 73(5): 802-808
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Topical 0.2% rapamycin to treat facial angiofibromas and hypomelanotic macules in tuberous sclerosis.
Knopfel N, et al. Actas Dermosifiliogr. 2014; 105(8): 802-803
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Successful treatment of subungual fibromas of tuberous sclerosis with topical rapamycin.
Muzic JG, et al. JAMA Dermatol. 2014; 150(9): 1024-1025
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A novel application of topical rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex.
Wataya-Kaneda M, et al. Arch Dermatol. 2012; 148(1): 138-139
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Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient.
Micozkadioglu H, et al. Ren Fail. 2010; 32(10): 1233-1236
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Rapamycin as a therapy of choice after renal transplantation in a patient with tuberous sclerosis complex.
Tarasewicz A, et al. Transplant Proc. 2009; 41(9): 3677-3682
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Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model.
Rauktys A, et al. BMC Dermatol. 2008; 8 : 1.
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